Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) due to dengue virus.
Identifieur interne : 000C77 ( Main/Exploration ); précédent : 000C76; suivant : 000C78Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) due to dengue virus.
Auteurs : Choong Yi Fong [Malaisie] ; Mi Mi Ko Khine [Birmanie] ; Alan Basil Peter [Malaisie] ; Wei Kang Lim [Malaisie] ; Faizatul Izza Rozalli [Malaisie] ; Kartini Rahmat [Malaisie]Source :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [ 1532-2653 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Encéphalite virale, Rate.
- imagerie diagnostique : Corps calleux, Encéphalite virale.
- étiologie : Encéphalite virale.
- Adolescent, Dengue, Femelle, Humains, Imagerie par résonance magnétique, Imagerie par tenseur de diffusion.
English descriptors
- KwdEn :
- MESH :
- complications : Dengue.
- diagnostic imaging : Corpus Callosum, Encephalitis, Viral.
- etiology : Encephalitis, Viral.
- pathology : Encephalitis, Viral, Spleen.
- Adolescent, Diffusion Tensor Imaging, Female, Humans, Magnetic Resonance Imaging.
Abstract
A 14-year-old girl presented with encephalopathy, delirium and ophthalmoplegia following a 3day history of high-grade fever. Brain MRI on day 6 of illness showed diffusion restricted ovoid lesion in the splenium of corpus callosum. Dengue virus encephalitis was diagnosed with positive PCR for dengue virus type-2 in both serum and cerebrospinal fluid. She made a complete recovery from day 10 of illness. Repeat brain MRI on day 12 of illness showed resolution of the splenial lesion. Serial diffusion tensor imaging (DTI) showed normal fractional anisotropy values on resolution of splenial lesion indicating that MERS was likely due to transient interstitial oedema with preservation of white matter tracts. This is the first reported case of MERS following dengue virus infection. It highlights the usefulness of performing serial DTI in understanding the underlying pathogenesis of MERS. Our case report widens the neurological manifestations associated with dengue infection and reiterates that patients with MERS should be managed supportively as the splenial white matter tracts are reversibly involved in MERS.
DOI: 10.1016/j.jocn.2016.10.050
PubMed: 27887978
Affiliations:
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Electronic address: cyfong@ummc.edu.my.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Khine, Mi Mi Ko" sort="Khine, Mi Mi Ko" uniqKey="Khine M" first="Mi Mi Ko" last="Khine">Mi Mi Ko Khine</name><affiliation wicri:level="1"><nlm:affiliation>Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Paediatric Neurology Unit, Yangon Children's Hospital, Yangon, Myanmar.</nlm:affiliation><country xml:lang="fr">Birmanie</country><wicri:regionArea>Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Paediatric Neurology Unit, Yangon Children's Hospital, Yangon</wicri:regionArea><wicri:noRegion>Yangon</wicri:noRegion></affiliation></author><author><name sortKey="Peter, Alan Basil" sort="Peter, Alan Basil" uniqKey="Peter A" first="Alan Basil" last="Peter">Alan Basil Peter</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Medical Imaging Department, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Medical Imaging Department, Faculty of Medicine, Universiti Teknologi MARA, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Wei Kang" sort="Lim, Wei Kang" uniqKey="Lim W" first="Wei Kang" last="Lim">Wei Kang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Paediatric Neurology, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Rozalli, Faizatul Izza" sort="Rozalli, Faizatul Izza" uniqKey="Rozalli F" first="Faizatul Izza" last="Rozalli">Faizatul Izza Rozalli</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Rahmat, Kartini" sort="Rahmat, Kartini" uniqKey="Rahmat K" first="Kartini" last="Rahmat">Kartini Rahmat</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Biomedical Imaging Department, University of Malaya Medical Centre, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia</title><idno type="eISSN">1532-2653</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Corpus Callosum (diagnostic imaging)</term><term>Dengue (complications)</term><term>Diffusion Tensor Imaging</term><term>Encephalitis, Viral (diagnostic imaging)</term><term>Encephalitis, Viral (etiology)</term><term>Encephalitis, Viral (pathology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Spleen (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Corps calleux (imagerie diagnostique)</term><term>Dengue ()</term><term>Encéphalite virale (anatomopathologie)</term><term>Encéphalite virale (imagerie diagnostique)</term><term>Encéphalite virale (étiologie)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie par tenseur de diffusion</term><term>Rate (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalite virale</term><term>Rate</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Corpus Callosum</term><term>Encephalitis, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Encephalitis, Viral</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Corps calleux</term><term>Encéphalite virale</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Encephalitis, Viral</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Encéphalite virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Dengue</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Imagerie par tenseur de diffusion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 14-year-old girl presented with encephalopathy, delirium and ophthalmoplegia following a 3day history of high-grade fever. Brain MRI on day 6 of illness showed diffusion restricted ovoid lesion in the splenium of corpus callosum. Dengue virus encephalitis was diagnosed with positive PCR for dengue virus type-2 in both serum and cerebrospinal fluid. She made a complete recovery from day 10 of illness. Repeat brain MRI on day 12 of illness showed resolution of the splenial lesion. Serial diffusion tensor imaging (DTI) showed normal fractional anisotropy values on resolution of splenial lesion indicating that MERS was likely due to transient interstitial oedema with preservation of white matter tracts. This is the first reported case of MERS following dengue virus infection. It highlights the usefulness of performing serial DTI in understanding the underlying pathogenesis of MERS. Our case report widens the neurological manifestations associated with dengue infection and reiterates that patients with MERS should be managed supportively as the splenial white matter tracts are reversibly involved in MERS.</div></front></TEI><affiliations><list><country><li>Birmanie</li><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Fong, Choong Yi" sort="Fong, Choong Yi" uniqKey="Fong C" first="Choong Yi" last="Fong">Choong Yi Fong</name></noRegion><name sortKey="Lim, Wei Kang" sort="Lim, Wei Kang" uniqKey="Lim W" first="Wei Kang" last="Lim">Wei Kang Lim</name><name sortKey="Peter, Alan Basil" sort="Peter, Alan Basil" uniqKey="Peter A" first="Alan Basil" last="Peter">Alan Basil Peter</name><name sortKey="Rahmat, Kartini" sort="Rahmat, Kartini" uniqKey="Rahmat K" first="Kartini" last="Rahmat">Kartini Rahmat</name><name sortKey="Rozalli, Faizatul Izza" sort="Rozalli, Faizatul Izza" uniqKey="Rozalli F" first="Faizatul Izza" last="Rozalli">Faizatul Izza Rozalli</name></country><country name="Birmanie"><noRegion><name sortKey="Khine, Mi Mi Ko" sort="Khine, Mi Mi Ko" uniqKey="Khine M" first="Mi Mi Ko" last="Khine">Mi Mi Ko Khine</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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